Table 1.
Real life experience with Sonidegib in advanced BCCs and/or multiple BCCs.
| Year | Authors | N | Age | (n) Sex | Location | Previous Treatments | Sonidegib Duration | (n) Outcome | AEs (n) Dropouts |
|---|---|---|---|---|---|---|---|---|---|
| 2020 | Conforti C. et al. [8] | 1 | 80 | F | Multiple la BCCs | Surgery | 3 m | CR | none |
| 2020 | Hou X. et al. [9] | 1 | 73 | M | Periocular laBCC | - | 6 m | CR | MS, vomiting |
| 2020 | Villani A. et al. [10] | 1 | 67 | M | laBCC | Surgery | 6 m | CR | None |
| 2021 | Conforti C. et al. [11] | 1 | 90 | - | Multiple + anal and rectal la BCC | - | >5 m | CR | MS, ↑ CPK |
| 2021 | Colnè J. et al. [12] | 4 | 94 88 70 70 |
F F F F |
Periocular laBCC Periocular laBCC Periocular laBCC Periocular laBCC |
- | 11 m 24 m 24 m 3 m |
CR PR PR PR |
Alopecia, dysgeusia, GI, MS, weight loss 1 dropout |
| 2021 | De Giorgi V. et al. [13] | 2 | - | - | Periocular La BCC | Surgery | - | (2) PR | Asthenia, CPK elevation, MS 0 dropouts |
| 2021 | Fania L. et al. [14] | 1 | 64 | M | laBCC | Surgery | 8 m | CR | Alopecia |
| 2021 | Hoffmann V. et al. [15] | 1 | 51 | M | Multiple BCCa | Surgery | 9 m | CR | Alopecia totalis, dysgeusia, MS, ↑ CPK, xerostomia, weight loss |
| 2021 | Moscarella E. et al. [16] | 5 | - | (4) M (1)F | laBCC laBCC |
Surgery (2) RT + surgery |
(1) 9 m (3) 6 m (1) lost |
(1) CR (3) PR (1) lost |
Alopecia, Fatigue, transaminase increase, MS 1 dropout |
| 2021 | Rokohl A. et al. [17] | 1 | - | - | Multiple + periocular BCC | Surgery | 6 m | CR | - |
| 2021 | Tarantino V. et al. [18] | 1 | 71 | F | Multiple BCCs | - | 6 m | CR | CPK increase, dysgeusia, MS 0 dropouts |
| 2021 | Toffoli L. et al. [19] | 9 | 81 89 90 48 78 52 83 59 75 |
F M M M M F F F F |
Multiple + la BCCs laBCC Multiple + laBCCs Multiple + laBCCs Multiple + la BCCs Multiple BCCs laBCCs laBCCs Multiple BCCs |
Surgery ECT + PDT - Surgery - Surgery Surgery - - |
21 m 9 m 5 m 7 m 7 m 25 m 5 m 4 m 5 m |
PR PR CR PR PR PR PR PR PR |
Alopecia, dysgeusia, GI, bone pain, muscle spasms 0 dropouts |
| 2021 | Villani A. et al. [20] | 18 | (16) M (2) F |
laBCC laBCC |
- | 6 m | 12CR 4PR 2SD |
None | |
| 2021 | Wang K. et al. [21] | 1 | 85 | M | laBCC | - | 8 m | PR | - |
| 2021 | Weis J. et al. [22] | 1 | 78 | F | laBCC | Surgery Cemiplimab |
8 m | CR | None |
| 2022 | Camela E. et al. [23] | 1 | 77 | F | laBCC | - | 10 m | CR | MS, dysgeusia, alopecia |
| 2022 | Leow L. J. et al. [24] | 10 | 54 65 62 67 77 46 37 49 56 59 |
F M M M F F F F M M |
laBCC laBCC laBCC laBCC laBCC laBCC laBCC laBCC laBCC laBCC |
- | 12 m 6 m 3 m 7 m 3 m 8 m 2 m 4 m 3 m 9 m |
CR CR CR CR PR PR CR CR CR CR |
Dysgeusia, MS, hyperhidrosis, alopecia, nausea, loss of appetite, fatigue, arthralgia 0 dropouts |
| 2022 | Puig S. et al. [25] | 2 | 79 69 |
F M |
laBCC laBCC |
Surgery RT - |
8 m 6 m |
CR CR |
Ageusia, MS, weight loss, alopecia 0 dropouts |
| 2022 | Toffoli L. et al. [26] | 2 |
59 83 |
F F |
laBCC laBCC |
- Surgery |
4 m 6 m |
PR CR |
MS, nausea, loss of appetite, bone pain 0 dropouts |
| 2022 | Trabelsi S. et al. [27] | 1 | 63 | M | Multiple + periocular laBCC | - | 2 m | CR | - |
| 2022 | Villani A. et al. [28] | 54 | 77.8 | - | Multiple + laBCCs | - | 7.2 M | (29) CR (21) PR (4) SD |
MS, dysgeusia, weight loss, alopecia 16 dropouts |
| 2023 | Piccerillo A. et al. [29] | 1 | 69 | F | laBCC | - | 7 m | CR | MS, alopecia |
| Total | 22 | 119 | - | - | - | - | - | (67) CR (45) PR (6) SD (1) lost |
18 dropouts |
Legend. laBCC (locally advanced BCC); MS (muscle spasms); m (months); CR (complete remission); PR (partial remission); SD (steady disease); RT (radiant therapy); PDT (photodynamic therapy); ECT (electrocoagulation therapy); ↑ (increase).