Table 3.

Patients’ treatment information, outcomes, and related AEs.

Pz	Previous TP	HHi	Following TP	CR	PR	SD	PD	TP Duration	AEs	Dosage Adjustments	AEs Onset	Path
1	Surgery	Sonidegib	Surgery	+ (biopsy)	-	-	-	14 m (ongoing)	Madarosi CPK ↑ Muscle spasms	200 mg/2 days 6 weeks holiday	10 m	-
2	RT 5FU RT	Sonidegib	-	+ (biopsy)	-	-	-	14 m (ongoing)	Weight loss Muscle spasms Alopecia Dysgeusia	-	4 m	Micronodular
3	Surgery	Sonidegib	-	+	-	-	-	6 m	Muscle spasms Dysgeusia fatigue Alopecia barbae	200 mg/2 days discontinuation	1 m	-
4	Surgery	Sonidegib	-	+ (biopsy)	-	-	-	20 m	Muscle spasms fatigue Dysgeusia Alopecia GI, Lipase ↑ Weight loss	200 mg/2 days 3 weeks holiday 200 mg/2 days	2 m	Nodular
5	Vismodegib	Sonidegib + RT	-	-	+	-	-	18 m (ongoing)	Ageusia, Telogen	-	-	Sclerosing and infiltrative
6	Surgery RT Vismodegib RT	Sonidegib	Imiquimod RT Cemiplimab	-	-	+	-	2 m	Muscle spasms Dysgeusia Nausea Fatigue Weight loss	200 mg/2 days discontinuation	1 m	Superficial and ulcerated
7	Surgery RT Vismodegib	Sonidegib	Cemiplimab	-	-	+	-	6 m	Cpk ↑ Muscle spasms	Drug holiday (3 w) 200 mg/2 days discontinuation	2 m	-
8	Surgery	Sonidegib	-	+ (biopsy)	-	-	-	10 m (ongoing)	Ageusia, telogen	-	4 m	Nodular
9	Imiquimod, Surgery Vismodegib	Sonidegib	-	-	+	-	-	4 m (ongoing)	-	-	-	Infiltrative
10	Surgery PDT	Sonidegib	-	-	-	+	-	4 m (ongoing)	Muscle spasms Fatigue	-	3 m	-
11	-	Sonidegib	-	+	-	-	-	4 m (ongoing)	Muscle spasms Alopecia	200 mg/2 days	2 m	Sclerosing and infiltrative

Legend. Tp (therapy); RT (radiotherapy); 5FU (5-Fluorouracil); m (months); CR (complete response); PR (partial response); SD (steady disease); PD (progression of disease); AEs (adverse events); ↑ (increase).