Table 4.

Discriminatory power for advanced fibrosis.

Biomarkers	AUC	95% CI	p-Value	Sensitivity	Specificity	Criterion	Correct Classification
sCr	0.87	0.80–0.92	<0.0001	77.3	87.4	>2.6	85.0%
S-C3M	0.61	0.52–0.69	0.11	59.1	65.8	>11.5	64.7%
U-C3M/Cr	0.81	0.72–0.88	<0.0001 (vs. sCr p = 0.64)	81.3	71.4	≤38.5	72.9%
S-C3C	0.72	0.64–0.79	<0.001 (vs. sCr p = 0.06)	54.6	83.8	>11.7	78.2%
U-C3C/Cr	0.58	0.48–0.67	0.35	50.0	73.6	>14.6	70.1%
S-PRO-C3	0.64	0.55–0.72	0.06	54.6	76.6	>11.9	72.2%
U-PRO-C3/Cr	0.52	0.42–0.61	0.86	25.0	86.8	>7.9	77.6%

ROC criteria: Banff score ci3 (advanced fibrosis) vs. ci0–ci2 (low–moderate fibrosis). AUC, area under the curve; CI, confidence interval.