Figure 6.

Microscopic representation of 3D ovarian cancer spheroid growth after combo therapy with epigenetic treatments and standard chemotherapy. In 3D culture, combinations of EGCG/CT, I3C/CT, and Pano/CT further suppress tumor growth in comparison to standard chemotherapy (CT) alone. EGCG/CT and Pano/CT have a more robust effect on volume inhibition, while Pano/CT promotes loss of 3D morphology. Lateral dispersion of disease can be visually observed in the CT-treated group. Two independent experiments were performed, including triplicates or tetraplicates for each treatment group.