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. 2023 Jul 1;13(7):1066. doi: 10.3390/biom13071066

Table 1.

Analysis of cytokines and growth factors’ secretion following epigenetic treatments.

GF/
CYTOKINE		 FUNCTION TREATMENTS
CONTROL EGCG I3C PANO
MEAN, SD MEAN, SD EFFECT MEAN, SD EFFECT MEAN, SD EFFECT
IL-10 Induces cancer proliferation, migration, and
immunosuppression		 183 ± 5 42 ± 4 77% Inline graphic 50 ± 9.3 73% Inline graphic 40 ± 1.5 78% Inline graphic
IL-8 Stimulates ovarian cancer growth and proliferation 187± 0.25 150 ± 0.46 20% Inline graphic 167 ± 5.7 11% Inline graphic 139 ± 5 25% Inline graphic
IL-11 Promotes chemoresistance, proliferation and survival of metastatic ovarian cancer cells 36 ± 3.6 18 ± 2.7 50% Inline graphic 2.9 ± 2.4 92% Inline graphic 0.8 ± 0.2 98% Inline graphic
IL-6R Correlated with aggressive behavior of high-grade ovarian cancer and poor prognosis when activated by IL-6 35.2 ± 3.6 41.6 ± 4.23 18% Inline graphic 21.9 ± 2 38% Inline graphic 34.78 ± 1.6 22% Inline graphic
TNF-RI Stimulates release of IL-6 and VEGF, induces peritoneal cancer spread 136 ± 2.2 30.5 ± 4.6 78% Inline graphic 7.8 ± 2.5 94% Inline graphic 12.2 ± 1.3 91% Inline graphic
 
RANTES (CCL5) Alters T-cells and NK cells function, induces cancer progression and resistance 136 ± 2.4 5.33 ± 1.3 96% Inline graphic 38.8 ± 0.91 71% Inline graphic 31.7 ± 1.46 77% Inline graphic
MCP-1 Facilitates proliferation, migration, angiogenesis and immunosuppression 134 ± 2.3 135.5 ± 4.9 11% Inline graphic 80.6 ± 4.3 40% Inline graphic 81.7 ± 1.4 39% Inline graphic

Optical Density (OD) signal was detected and compared between samples using Image J software. Mean and SD are represented in OD units, while effect is calculated in percent decrease (downward arrow) or increase (upward arrow) in relation to the control or drug free treatment group. Microsoft Word 16.73 was used to produce this table.