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. 2023 Jul 19;13(7):1092. doi: 10.3390/brainsci13071092

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The effects of DMF (60 mg/kg; 30 mg/kg twice a day; p.o.), BCP (2.5, 5 mg/kg/day; p.o.), and the combination of a CB₂ antagonist AM630 (1 mg/kg; i.p.) with BCP (5 mg/kg/day; p.o.) on the levels of anti-inflammatory and pro-inflammatory cytokines in the EAE mice serums; (A) TNF-α, (B) IL-6; (C) IL-17; (D) IL-10; and (E) IL-17/IL-10 ratio. Data were presented as Mean ± SEM, n = 6 animals in each group per experiment protocol. Two-way ANOVA and Tukey’s multiple comparisons test were performed. (*) indicates the comparison between varying doses of BCP and DMF groups to the vehicle group, **: p < 0.01, and ***: p < 0.001; (⁺) makes comparisons between the vehicle and sham groups, ⁺⁺⁺: p < 0.001; ^# in comparison to DMF group in each graph, ^#: p < 0.05, ^##: p < 0.01, and ^###: p < 0.001.

The effects of DMF (60 mg/kg; 30 mg/kg twice a day; p.o.), BCP (2.5, 5 mg/kg/day; p.o.), and the combination of a CB₂ antagonist AM630 (1 mg/kg; i.p.) with BCP (5 mg/kg/day; p.o.) on the levels of anti-inflammatory and pro-inflammatory cytokines in the EAE mice serums; (A) TNF-α, (B) IL-6; (C) IL-17; (D) IL-10; and (E) IL-17/IL-10 ratio. Data were presented as Mean ± SEM, n = 6 animals in each group per experiment protocol. Two-way ANOVA and Tukey’s multiple comparisons test were performed. (*) indicates the comparison between varying doses of BCP and DMF groups to the vehicle group, **: p < 0.01, and ***: p < 0.001; (⁺) makes comparisons between the vehicle and sham groups, ⁺⁺⁺: p < 0.001; ^# in comparison to DMF group in each graph, ^#: p < 0.05, ^##: p < 0.01, and ^###: p < 0.001.