Table 1.

Clinical scoring of EAE mice [28].

Score	Clinical Manifestations (Significant Comment)
0	Without clinical symptoms
1	Partly limp tail (a tip of the tail droops, normal gait)
2	Paralyzed tail (tail droops, normal gait)
3	Uncoordinated movement, hind limb paresis (uncoordinated gait, hind limbs responding to pinching, tail limps)
4	One paralyzed hind limb (uncoordinated gait with dragging one hind limb, one hind limb not responding to pinch, tail limps)
5	Two paralyzed hind limbs (uncoordinated gait with both hind limbs dragging, two hind limbs not responding to pinch, tail limps)
6	Hind limbs paralyzed, weak forelimbs (uncoordinated gait with forelimbs struggling to pull body, tail limps, forelimbs reflex following pinching)
7	Hind limbs paralyzed, one paralyzed forelimb (no movement of the mouse, one forelimb responding to a toe pinch, tail limps)
8	Hind limbs paralyzed, both forelimbs paralyzed (no movement of the mouse, both forelimbs do not respond to a toe pinch, tail limps)
9	Moribund (worsened breathing, no movement)
10	Death