Table 4.

Factors affecting prognosis in MDS patients in univariate analysis with the absolute monocyte count as a continuous variable (see Figure 3A–C) and two multivariate models (multivariate I: AMC together with the degree of cytopenias, bone marrow blast count, and cytogenetic risk groups according to IPSS-R; multivariate II: AMC together with the single IPSS-R risk groups).

	Univariate			Multivariate I			Multivariate II
	HR	95% CI	p	HR	95% CI	p	HR	95% CI	p
Hb  <  10 g/dL	1.48	1.23; 1.79	<0.001	1.59	1.30; 1.94	<0.001
Neutrophil count  <  0.5  ×  109/L	1.74	1.32; 2.30	<0.001	0.94	0.70; 1.26	0.684
Platelet count  <  100  ×  109/L	1.56	1.23; 1.99	<0.001	1.67	1.36; 2.05	<0.001
Bone marrow blasts  >  5%	2.81	2.29; 3.45	<0.001	2.09	1.66; 2.63	<0.001
IPSS-R cytogenetic risk category
good vs. very good	1.67	0.86; 3.25	0.130	2.13	1.09; 4.17	0.027
intermediate vs. very good	2.48	1.24; 4.96	0.010	2.81	1.40; 5.66	<0.001
poor vs. very good	2.55	1.22; 5.32	0.014	2.68	1.28; 5.63	<0.001
very poor vs. very good	8.15	4.01; 16.55	<0.01	7.45	3.61; 15.37	<0.001
IPSS-R category
low vs. very low	1.44	0.92; 2.25	0.113				1.43	0.91; 2.25	0.119
intermediate vs. very low	2.16	1.37; 3.41	<0.001				2.14	1.35; 3.39	0.001
high vs. very low	4.03	2.51; 6.46	<0.001				3.82	2.37; 6.14	<0.001
very high vs. very low	7.10	4.41; 11.43	<0.001				7.23	4.48; 11.67	<0.001
Absolute monocyte count as a continous variable	See Figure 3A			See Figure 3B			See Figure 3C