Table 2.
Comparison of baseline data in patients with and without severe WMLs.
| Variables | Severe WMLs | p Value | |
|---|---|---|---|
| Yes, n =148 | No, n = 174 | ||
| Demographic characteristics | |||
| Age, years | 66.7 ± 12.5 | 63.0 ± 10.5 | 0.004 |
| Male, n (%) | 89 (60.1) | 96 (55.2) | 0.369 |
| Vascular risk factors, n (%) | |||
| Hypertension | 113 (76.4) | 120 (69.0) | 0.140 |
| Diabetes mellitus | 61 (41.2) | 66 (37.9) | 0.548 |
| Hyperlipidemia | 17 (11.5) | 21 (12.1) | 0.872 |
| Coronary heart disease | 30 (20.3) | 24 (13.8) | 0.121 |
| Smoking | 61 (41.2) | 70 (40.2) | 0.857 |
| Clinical data | |||
| Previous statin therapy, n (%) | 48 (32.4) | 52 (29.9) | 0.622 |
| Previous antiplatelet therapy, n (%) | 51 (34.5) | 50 (28.7) | 0.272 |
| Systolic blood pressure, mmHg | 145.0 ± 24.4 | 137.9 ± 20.9 | 0.005 |
| Diastolic blood pressure, mmHg | 83.4 ± 13.5 | 81.1 ± 11.9 | 0.106 |
| Baseline NIHSS, score | 2.0 (0, 4.0) | 2.0 (0, 4.0) | 0.476 |
| Stroke etiology, n (%) | 0.012 | ||
| Large artery atherosclerosis | 81 (54.7) | 74 (42.5) | 0.029 |
| Cardioembolic | 25 (16.9) | 21 (12.1) | 0.218 |
| Small vessel occlusion | 32 (21.6) | 52 (29.9) | 0.092 |
| Others | 10 (6.8) | 27 (15.5) | 0.014 |
| Laboratory data | |||
| Total cholesterol, mmol/L | 3.8 ± 0.9 | 3.9 ± 1.0 | 0.170 |
| Triglyceride, mmol/L | 1.3 (1.0, 2.0) | 1.4 (1.1, 2.2) | 0.175 |
| Low density lipoprotein, mmol/L | 1.9 (1.5, 2.5) | 2.1 (1.6, 2.6) | 0.147 |
| High density lipoprotein, mmol/L | 1.0 (0.9, 1.2) | 1.0 (0.9, 1.2) | 0.278 |
| Homocysteine, mmol/L | 15.1 ± 6.0 | 12.3 ± 4.3 | 0.001 |
| Baseline blood glucose, mmol/L | 6.9 ± 2.3 | 6.8 ± 2.9 | 0.739 |
| Hs-CRP, mg/L | 5.2 (2.6, 11.5) | 4.0 (1.3, 12.1) | 0.124 |
| CitH3, ng/mL | 45.2 (17.8, 82.6) | 19.6 (10.3, 46.5) | 0.001 |
Abbreviations: CitH3, Citrullinated histone H3; Hs-CRP, hypersensitive C-reactive protein; NIHSS, National Institute of Health Stroke Scale; WMLs, white matter lesions. p indicated the statistical difference in the baseline data between groups. Informed consent was obtained from all subjects involved in the study. p indicated the statistical difference in the baseline data between groups.