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. 2023 Jul 14;11(7):1993. doi: 10.3390/biomedicines11071993

Figure 3.

Figure 3

Primary structure and helices organization of the MOP receptor, depicting posttranslational modifications (A) [19,49,50]. An external view from the extracellular site of the structure of human MOP bound to the agonists morphine (B) and SR17018 (5,6-dichloro-3-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-1H-benzimidazol-2-one) (C) shows the interaction of both agonists with transmembrane domains 3, 6, and 7. Figures were obtained from the Protein Data Bank [51] and correspond to PDB ID 8EF6 and 8EFL [52] and drawn with the free web-based open-source toolkit Molstar (https://molstar.org/ (accessed on 17 May 2023) [53]. Two-dimensional structures of morphine and SR17018 were drawn with KingDraw software [54] (version 1.1.0) (https://www.kingdraw.cn/en/ (accessed on 17 May 2023)).