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. 2023 Jul 14;11(7):1993. doi: 10.3390/biomedicines11071993

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Representation of the main interactions of MOP-biased agonists PZM21 (1-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-3-[(2S)-1-thiophen-3-ylpropan-2-yl]urea) and FH210 (a naphthyl-substituted acryl amide derivative of PZM21) with MOP-Gi complex (see text for details). The structures were obtained from the Protein Data Bank (PDB ID 7SBF and 7SCG, [62]) and drawn with the free web-based open-source toolkit Molstar (https://molstar.org/ (accessed on 17 May 2023)) [53]). Amino acid positions are numbered according to Ballesteros and Weinstein [57].