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. 2023 Jul 10;15(14):3561. doi: 10.3390/cancers15143561
NSCLC Non-small cell lung cancer
EGFR Epidermal growth factor receptor
KRAS Kirsten rat sarcoma virus
BRAF v-raf murine sarcoma viral oncogene homolog B1
ALK Anaplastic lymphoma kinase
ROS1 Proto-oncogene tyrosine–protein kinase ROS
RET Rearranged during transfection proto-oncogene
MET Mesenchymal–epithelial transition
ERBB2 erb-b2 receptor tyrosine kinase 2
NTRK Neurotrophic tyrosine receptor kinase
HGF Hepatocyte growth factor
AMPK AMP-activated protein kinase
LKB1 Liver kinase B1
GCN Gain of copy number
FDA U.S. Food and Drug Administration
EMA European Medicines Agency
po Oral
DLT Drug limiting toxicity
b.i.d. Twice a day
R2PD Recommended Phase II dose
ORR Overall response rate
PFS Progression-free survival
DOR Duration of response
IO Immunotherapy
IHC Immunohistochemistry
CEP7 Chromosome 7 centromere
ctDNA Circulating tumor DNA
cfDNA Circulating-free DNA
CTCs Circulating tumor cells
FFPE Fresh-frozen paraffin-embedded
PPA Positive percent agreement
NPA Negative percent agreement
OA Overall agreement
NCCN National Comprehensive Cancer Network
Teliso-V Telisotuzumab vedotin