Table 3.
Principal component analysis outcomes. Scores were created from concentrations of 13 human inflammatory cytokines/chemokines, of which 3 components were retained. High loadings (>|0.3|) are indicated in bold.
| Cytokine | PC1 | PC2 | PC3 | |||
|---|---|---|---|---|---|---|
| Loadings (% contribution to the component) | ||||||
| IL-12p70 | −0.37 | (13) | −0.12 | (1) | −0.27 | (7) |
| IFN-g | −0.35 | (12) | −0.18 | (3) | −0.05 | (0) |
| IL-1b | −0.34 | (12) | −0.20 | (4) | −0.09 | (1) |
| IL-8 | −0.31 | (10) | 0.19 | (4) | 0.03 | (0) |
| MCP-1 | −0.16 | (3) | 0.48 | (23) | 0.08 | (1) |
| MIP-1b | −0.20 | (4) | 0.43 | (19) | 0.29 | (9) |
| BDNF | −0.23 | (5) | 0.37 | (13) | −0.34 | (12) |
| TNF-a | −0.20 | (4) | −0.32 | (10) | 0.07 | (1) |
| IFN-a2 | −0.30 | (9) | −0.31 | (9) | 0.00 | (0) |
| IFN-b | −0.30 | (9) | 0.16 | (3) | −0.50 | (25) |
| IL-18 | −0.22 | (5) | 0.22 | (5) | 0.46 | (21) |
| IL-17A | −0.24 | (6) | −0.24 | (6) | 0.37 | (14) |
| IL-6 | −0.29 | (8) | −0.03 | (0) | 0.31 | (10) |
| Model metrics | ||||||
| Variance (in %) | 41 | 15 | 9 | |||
| Eigenvalue | 5.3 | 1.9 | 1.1 | |||
BDNF = brain derived neurotrophic factor, IFN = interferon, IL = interleukin, MCP = monocyte chemoattractant protein, MIP = macrophage inflammatory protein; TNF = tumor necrosis factor.