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Summary of the strategies to target wtp53 and mutp53 in human cancers. For activating wtp53, drug development has been focused on strategies to disrupt the interaction between p53 and its negative regulators MDM2/MDMX. For human cancers expressing mutant p53, drug development has been focused on strategies to restore wild-type p53 activities to mutp53. In addition, drugs to eradicate mutp53 and induce synthetic lethality of tumor cells expressing p53 mutants have also been explored.
