TABLE 3.
Specificity of spontaneous G:C→T:A reversions formed in multiple mutants lacking DNA glycosylases specific for oxidized purines and pyrimidines
| Genotype | Lac+ revertants per 109 cells
|
||||
|---|---|---|---|---|---|
| Expt 1 | Expt 2 | Expt 3 | Avg ± SD | Relative to fpg mutY (approx) | |
| Wild type (CC104) | 1.6 | 0.3 | 3.5 | 1.8 ± 1.6 | N/Aa |
| fpg mutY | 5,900 | 4,000 | 5,400 | 5,100 ± 990 | 1 |
| fpg mutY nei | 7,100 | 8,100 | 13,000 | 9,400 ± 3,200 | 1.8 |
| fpg mutY nth | 6,400 | 6,800 | 7,900 | 7,000 ± 780 | 1.4 |
| fpg mutY nei nth | 6,800 | 9,200 | 8,000 | 8,000 ± 1,200 | 1.6 |
a
Not applicable.