Table 1.
Preoperative patient characteristics, prior treatment, and surgical details.
| Non-SMM Depletion (n = 47) | SMM Depletion (n = 37) | p-Value * | |
|---|---|---|---|
| Age (years), (mean, SD) | 65 (9) | 64 (9) | 0.425 |
| Sex (male), (n, %) | 36 (76.5) | 32 (86.5) | 0.386 |
| BMI (kg/m2), (mean, SD) | 24.3 (6.8) | 20.2 (4.8) | <0.003 |
| SMA (cm2), (mean, SD) | 146.2 (29.4) | 119.3 (23.0) | <0.001 |
| SMRA (HU), (mean, SD) | 39.7 (8.0) | 41.2 (6.8) | 0.360 |
| IMAT (cm2), (mean, SD) | 19.4 (12.8) | 13.7 (10.0) | 0.029 |
| IMATI (cm2/m2), (mean, SD) | 6.7 (4.3) | 4.4 (3.1) | 0.007 |
| Cardiovascular disease, (n, %) | 13 (27.7) | 7 (18.9) | 0.499 |
| Pulmonary disease, (n, %) | 16 (34.0) | 16 (43.2) | 0.525 |
| Renal disease, (n, %) | 5 (10.6) | 3 (8.1) | 0.986 |
| Diabetes, (n, %) | 6 (12.8) | 3 (8.1) | 0.741 |
| ASA score ≥ 3, (n, %) | 32 (68.1) | 24 (64.9) | 0.938 |
| Smoking, (n, %) | 20 (46.5) | 20 (57.1) | 0.480 |
| Alcohol consumption, (n, %) | 25 (53.2) | 28 (75.7) | 0.089 |
| Prior locoregional RT, (n, %) | 17 (36.1) | 18 (48.6) | 0.396 |
| Prior chemotherapy, (n, %) | 11 (23.4) | 11 (29.7) | 0.686 |
| Surgical indication, (n, %) | 0.664 | ||
| Primary | 30 (63.8) | 21 (56.8) | |
| Salvage | 17 (36.2) | 16 (43.2) | |
| Tumor location, (n, %) | 0.630 | ||
| Laryngeal | 31 (66.0) | 24 (64.9) | |
| Pharyngeal | 9 (19.1) | 5 (13.5) | |
| Laryngo-pharyngeal | 7 (14.9) | 8 (21.6) | |
| Procedure, (n, %) | 0.660 | ||
| Total laryngectomy | 25 (53.2) | 15 (45.9) | |
| Pharyngolaryngectomy | 22 (46.8) | 20 (54.1) | |
| Neck dissection, (n, %) | 44 (93.6) | 35 (94.6) | 1.000 |
| Flap reconstruction, (n, %) | 21 (44.7) | 19 (51.4) | 0.698 |
* Significant p-values (<0.05) are displayed in bold characters. SD: standard deviation; SMM: skeletal muscle mass; BMI: body mass index; SMA: skeletal muscle area; SMRA: skeletal muscle radiation attenuation; HU: Hounsfield unit; IMAT: intermuscular adipose tissue; IMATI: intermuscular adipose tissue index; ASA: American Society of Anesthesiologists; RT: radiotherapy.