Skip to main content
. Author manuscript; available in PMC: 2023 Jul 28.
Published in final edited form as: Eur J Med Chem. 2022 Aug 6;242:114638. doi: 10.1016/j.ejmech.2022.114638

Table 3.

Anti-Proliferation Activities of Compound Series 7 against HT-1080, RD, GCT, and MCF-7 cells and Selectivity Index (SI) of HT-1080 vs MCF-7.

graphic file with name nihms-1916857-t0004.jpg
Compound IC50 (nM) SI
(HT-1080 vs MCF-7)
HT-1080 RD GCT MCF-7
7a 1148 ± 90 1072 ± 80 1274 ± 180 > 20000  >17
7b 3228 ± 854 5600 ± 898 8862 ± 1487 > 20000 >6
7c 5566 ± 443 6152 ± 535 4034 ± 482 > 20000 >4
7d > 20000 > 20000 > 20000 > 20000 n.d.
7e > 20000 > 20000 > 20000 > 20000 n.d.
7f > 20000 > 20000 > 20000 > 20000 n.d.
FiVe1 1564 ± 288 3095 ± 555 1686 ± 349 > 20000 >13

n.d.: not determined