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Mouse Pharmacokinetics of Compounds 4e and FiVe1.
| 4e | FiVe1 | ||
|---|---|---|---|
| parameter | po 10 mg/kg | ip 1 mg/kg | po 25 mg/kg |
| AUC0-last (ng.h/mL) | 371.33 ± 68.08 | 208.33 ± 32.50 | 309.78 ± 44.41 |
| AUC0-inf (ng.h/mL) | 534.33 ± 152.23 | 211.33 ± 34.56 | 339.21 ± 151.72 |
| T1/2 (h) | 4.68 ± 3.73 | 0.59 ± 0.09 | 4.57 ± 1.61 |
| Tmax (h) | 0.67 ± 0.29 | 0.25 ± 0.00 | 0.5 ± 0.00 |
| Tlast (h) | 8 | 4 | 18 |
| Cmax (ng/mL) | 154.67 ± 20.60 | 197.00 ± 44.84 | 110.43 ± 41.91 |
