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Microsomal Stability Parameters Obtained for the Selected Compounds.
| Compound | Structure | T1/2 (min) | CLint(mic) (uL/min/mg) | Remaining (T= 60 min) |
|---|---|---|---|---|
| S10 |
|
6.7 | 205.8 | 0.4% |
| S12 |
|
32.5 | 42.6 | 29.6% |
| 4c |
|
2.1 | 657.4 | 0.1% |
| 4e |
|
1.7 | 805.3 | 0.0% |
| 11a |
|
>145 | <9.6 | 78.7% |
| 11d |
|
19.1 | 72.5 | 10.5% |
| 11e |
|
42.7 | 32.5 | 35.7% |
| 11j |
|
35.5 | 39.0 | 28.9% |
| FiVe1 |
|
11.9 | 116.1 | 3.2% |
