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Simplified scheme of the mechanism behind the Thymidine Kinase-Ganciclovir (Tk-GCV) system for cell ablation. Purple circles represent cells that do not express the Tk transgene; green circles represent cells that express the Tk transgene under the chosen cell-specific promoter. Only the cells expressing Tk undergo apoptosis by modification of the ganciclovir prodrug to its active form. Prom—promoter; Tk—Thymidine kinase; GCV—ganciclovir.
