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. 2023 Jul 14;12(14):1854. doi: 10.3390/cells12141854

Figure 4.

Figure 4

Drug sensitivity test using cryobiopsy specimen-derived LCOs for precision medicine. (A) LCOs were seeded in a micropillar with 5000 cells/pillar and soaked in medium. (B) After treatment with multiple doses of several drugs, the viability of LCOs was checked using the fluorescent dye calcein AM. The maximum drug concentration was 20 µM (each drug). (C) Survival rates of LCOs after multiple doses of afatinib, osimertinib, alectinib, and crizotinib. (D) The IC50 and AUC of each drug were calculated.