Table 2.
Univariable analysis for AKI including all variables.
| Patient’s Characteristics | HR Estimate |
95% CI | p-Value | |
|---|---|---|---|---|
| Lower Limit | Upper Limit | |||
| Age at transplant (years) | 1.00 | 0.99 | 1.01 | 0.830 |
| Gender (female versus male) | 1.05 | 0.83 | 1.35 | 0.654 |
| Race (Caucasian versus non-Caucasian) | 0.90 | 0.58 | 1.40 | 0.634 |
| BMI (Kg/m2) | 1.02 | 1.00 | 1.05 | 0.105 |
| HCT-CI (score < 2 versus score ≥ 2) | 1.69 | 1.27 | 2.25 | <0.001 |
| Hypertension | 1.15 | 0.86 | 1.54 | 0.335 |
| Diabetes mellitus | 1.29 | 0.82 | 2.02 | 0.269 |
| Congestive heart failure | 1.41 | 0.91 | 2.20 | 0.128 |
| Chronic kidney disease | 2.11 | 1.36 | 3.27 | 0.001 |
| Hematologic diagnosis: | ||||
| Multiple myeloma versus lymphoma | 1.51 | 1.10 | 2.08 | 0.011 |
| Multiple myeloma versus leukemia | 1.44 | 1.07 | 1.92 | 0.015 |
| Leukemia versus lymphoma | 1.05 | 0.78 | 1.41 | 0.728 |
| Multiple myeloma versus (lymphoma + leukemia) | 1.46 | 1.12 | 1.90 | 0.005 |
| Type of HSCT (allogeneic versus autologous) | 0.84 | 0.66 | 1.08 | 0.169 |
| Type of donor (related versus unrelated) | 1.14 | 0.86 | 1.52 | 0.368 |
| Previous radiotherapy | 1.09 | 0.81 | 1.47 | 0.573 |
| Conditioning regimen (non-myeloablative versus myeloablative) | 1.27 | 0.84 | 1.95 | 0.260 |
| basal eGFR (ml/min/1.73 m2) | 0.99 | 0.99 | 1.00 | 0.012 |
| Graft source (peripheral blood versus bone marrow) | 1.36 | 0.88 | 2.12 | 0.170 |
| GVHD prophylaxis (methotrexate versus others) | 1.03 | 0.73 | 1.46 | 0.849 |
| At hospital admission day: | ||||
| Hemoglobin (gr/dL) | 1.01 | 0.94 | 1.09 | 0.752 |
| Leukocytes * (cells/mm3) | 1.07 | 1.04 | 1.09 | <0.001 |
| Neutrophils * (cells/mm3) | 1.06 | 0.88 | 1.26 | 0.547 |
| Lymphocytes * (cells/mm3) | 1.23 | 1.13 | 1.34 | <0.001 |
| Platelets * (/μL) | 1.01 | 0.99 | 1.02 | 0.841 |
| Urea (mg/dL) | 1.01 | 1.00 | 1.02 | 0.019 |
| Uric acid (mg/dL) | 1.01 | 0.97 | 1.04 | 0.662 |
| Calcium (mg/dL) | 1.06 | 0.85 | 1.31 | 0.598 |
| Phosphate (mg/dL) | 0.92 | 0.77 | 1.10 | 0.367 |
| Reactive C protein ** (mg/dL) | 1.02 | 1.01 | 1.03 | <0.001 |
| Lactate dehydrogenase ** (U/L) | 1.05 | 1.03 | 1.07 | <0.001 |
| Albumin (mg/dL) | 1.00 | 0.96 | 1.04 | 0.847 |
| Alanine transaminase (U/L) | 1.00 | 0.99 | 1.00 | 0.081 |
| Total bilirubin (mg/dL) | 0.91 | 0.62 | 1.32 | 0.611 |
| Platelet-to-lymphocyte ratio | 1.00 | 1.00 | 1.00 | <0.001 |
*—for each rise of 1000; **—for each rise of 10; BMI—body mass index; HCT-CI—hematopoietic stem cell transplant comorbidity index; Nr—number; HSCT—hematopoietic stem cell transplant; eGFR—estimated glomerular filtration rate; GVHD—grafts versus host disease.