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. 2023 Jul 13;12(14):1843. doi: 10.3390/cells12141843

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematic representation showing the increasingly complex (from left to right) RT gut in vitro platforms used and developed in the present study. RTpiMI epithelial (EP) cells cultured on (1) ThinCert™ culture inserts (TC), (2) TC inserts coated with Matrigel^® matrix (MM), (3) TC inserts coated with the Matrigel^® matrix enriched with RTskin01 fibroblasts (MMFb), or (4) the synthetic, highly porous Alvetex™ scaffold (AV) populated with fibroblasts (Fb) that synthesize and deposit collagen (Col) between them and at the interface with the apical surface, creating an anchorage site for the epithelial cells (EP). The image was created using Biorender.com.