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. 2023 Jul 21;15(14):3701. doi: 10.3390/cancers15143701

Figure 1.

Figure 1

Heatmap illustrating the vitreous profiles of twenty-six cytokines differentially expressed in choroidal melanoma (CM)-bearing eyes compared to CM-free control eyes. Green indicates increased expression while red indicates reduced expression. The tumor group included 18 CM patients, of which 11 were classified as having Class 1—low risk (GEP1) and 7 as having Class 2—high risk (GEP2) tumors based on the primary tumor biopsy-based gene expression profiling (GEP) test used for metastatic risk prediction (DecisionDx-UM®) [28]. The control group included 14 non-CM patients. Vitreous cytokine levels are based on the MFI (median fluorescence intensity) values that were extracted/used for relative quantification of the cytokine abundance (see Methods) and are displayed here on a logarithmic scale (see Table S1 for the full names of the cytokines and details on individual cytokine analysis results).