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. 2023 Jul 21;15(14):3708. doi: 10.3390/cancers15143708

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(a) HeatMap demonstrating the metabolites differences between cutaneous melanoma versus mucosal and uveal. (b) Random Forest analysis, cutaneous versus mucosal and uveal melanomas presented with distinct levels of 3-hydroxykynurenine and kynurenic acid. (c) Scheme of Kynurenine Pathway. (d) Conversion rate (mean, SD) estimated by kynurenine/tryptophan ratio (Kyn/Tryp), levels of tryptophan, and levels of kynurenine according to melanoma subtypes. (e) Levels of 3-hydroxykynurenine and kynurenic acid by melanoma subtypes, and kynurenic acid/3-hydroxykynurenine (KA/3-HKyn) ratio. ns = not statistically significant; ** p < 0.01; **** p < 0.0001.