Table 2.

Primary limitations and possible solutions in liquid biopsy.

Primary Limitations	Possible Solutions
Small sample size	-Multi-centric samples collections
Heterogeneity in protocols	Expert consensus on the protocols
Heterogeneity of the participants	Correct clinical classification should be validated by traditional techniques and genetic background should be taken into consideration while conducting analysis
Expensive cost	Major laboratories should work on cost-effectiveness to get the easy penetration of the liquid biopsy test world-wide