Figure 8.

Re-analysis of an scRNA-seq dataset obtained from the atherosclerotic core of atherosclerotic patients undergoing carotid endarterectomy (CEA). The scRNA-seq dataset analyzed was from the NCBI GEO (National Center for Biotechnology Information Gene Expression Omnibus; NCBI GEO; GSE159677) and is based on material from three human CEA patients (Alsaigh et al. [34]). Here, re-analysis was conducted for the expression of TIMP-1, CD74, MIF, and CXCR4 in the different single-cell populations. (a) Uniform Manifold Approximation and Projection (UMAP) of the atherosclerotic core (AC) with thirteen clusters identified by Louvain clustering. (b) Feature plots, (c) violin plots, and (d) dot plots of the genes of interest in the different cell populations found in the AC including B cells (BCs); T cells (TCs); natural killer T cells (NKTCs); red blood cells (RBCs); vascular smooth muscle cells (VSMCs); endothelial cells (ECs); granulocytes (GCs); dendritic cells (DCs); monocytes (MOs); and macrophages (MΦ).