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. 2023 Jul 22;15(14):3721. doi: 10.3390/cancers15143721

Figure 1.

Figure 1

The 2EF binding to Trop-2-expressing cancer cells. (A) Recognition of Trop-2 by 2EF-Alexa488 on MTE4-14/Trop-2 transfectants. Confocal microscopy IF analysis of cells cultured in adhesion to substrate was performed with anti-Trop-2 mAb directly conjugated to chromophores. The 2G10-Alexa488 and AbT16-Alexa488 were used as anti-Trop-2 benchmarks. Scale bars, 10 µm. (B) IF analysis of MCF-7 epithelioid and MDA-MB231 mesenchymal breast cancer cells. White arrowheads indicate cell–cell junctions with higher differential binding of 2EF versus 2G10. Scale bars, 10 µm.