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Hu2EF immune-mediated killing of Trop-2-expressing cancer cells. (A) Flow cytometry analysis of Hu2EF binding to target MCF-7 cells. (B) Hu2EF-mediated ADCC dose-response curve, following incubation of MCF-7 target cells with serial dilutions of the Hu2EF mAb and effector Jurkat NF-kB/NFAT-reporter cells. Luminescence data upon NF-kB/NFAT-reporter activation (three replica wells per data point) were plotted against mAb concentration. Error bars: SEM.
