Figure 6.

Growth inhibition of Trop-2-expressing HT29 colon cancer cells by 2EF versus 2G10. HT29 cells were seeded in culture at high (A) versus low (B) cell density. Murine 2EF or 2G10 mAb were added every 24 h. (C,D) Immunotherapy of HT29 colon cancer xenografts. Injected mice were randomized (n = 16 per group) and treated weekly with 30 mg/kg of the 2EF, 2G10 or AR47A6.4.2 mAb until sacrifice. Treatment began when (C) tumors reached an average volume of 100 mm³ (established tumor) or (D) at the time of tumor cell injection (isolated cells), as indicated (red arrows). Error bars: SEM.