Table 1.
A list of substrate proteins degraded via 26S or 20S proteasome.
| Proteasome | Ubiquitin | E3 Ligase | Substrate | Mediator | Disease | References |
|---|---|---|---|---|---|---|
| 26S | dependent | MDM2 | p53 | RNF31 | Cancer | [46,51] |
| HIF1α | Cancer | [47] | ||||
| Siah2 | ASPP2 | Cancer | [52] | |||
| PHD3 | Cancer | [53] | ||||
| HIPK2 | Cancer | [49] | ||||
| CHK2 | Cancer | [54] | ||||
| HDAC3 | Neurodegenerative disease | [55] | ||||
| Cullin3 | HIF1α | RhoBTB3 | Cancer | [56] | ||
| ULK1 | KLHL20 | Cancer, Diabetes | [57] | |||
| Roquin2 | ASK1 | Cancer | [50] | |||
| VHL | HIF1α | Cancer | [58] | |||
| KEAP1 | IKKβ | Cancer | [59] | |||
| KPC1 | p105 | Cancer | [60] | |||
| CHIP | sGC | Cardiovascular disease | [61] | |||
| Smurf1 | PIPKIγ | Cancer | [62] | |||
| CRL4 | GRK2 | Gβ2 | Cardiovascular disease | [63] | ||
| WWP1 | KLF5 | Cancer | [64] | |||
| Itch | Bid | Cancer | [65] | |||
| COP1 | MTA1 | Cancer | [66] | |||
| independent | ODC | Antizyme1 | Cancer | [67] | ||
| TS | Cancer | [68] | ||||
| 20S | independent | p53 | Cancer | [69] | ||
| p53 | Isg15 | Cancer | [70] | |||
| p35 | Neurodegenerative disease | [71] | ||||
| p21 | 14-3-3τ | Cancer | [72] | |||
| tau | Neurodegenerative disease | [73] | ||||
| α-synuclein | Neurodegenerative disease | [74] | ||||
| c-Myc | Antizyme2 | Cancer | [75] | |||
| IκBα | Cancer | [76] | ||||
| Aurora-A | AURKAIP1 Antizyme1 | Cancer | [77,78] | |||
| p130 | pp71 | Cancer | [79] | |||
| Rb | MDM2 | Cancer | [80] | |||
| SE | [81] |