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. 2023 Jul 8;24(14):11236. doi: 10.3390/ijms241411236

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Glycine targets and pathways. According to the International Union of Basic & Clinical Pharmacology (IUPHAR) glycine has different targets such as Natural/Endogenous Targets: glycine receptor (consisting of glycine receptor α1, α2, α3, α4 and β subunits), ionotropic glutamate receptors co-agonist (GluN1, GluN2A, GluN2B, GluN2C and GluN2D) and GPRC6 Receptor. Transporters moving this compound across a lipid membrane with proton-coupled amino acid transporter 1, vesicular inhibitory amino acid transporter, Proton-coupled Amino acid Transporter 2, GlyT1, GlyT2, B0AT1, B0AT2, B0AT3, NTT4, sodium-coupled neutral amino acid transporter 1, sodium-coupled neutral amino acid transporter 2, sodium-coupled neutral amino acid transporter 4, Sodium-coupled neutral amino acid transporter 5 [27,28,29,30]. These may be the targets involved in the signaling by which glycine exerts its effect on the different cell lines of living organisms.