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Proposed model illustrating that EC-specific knockout of Mlkl (MlkliΔEC/iΔEC) alleviates liver fibrosis in NASH by mitigating the activation of TGFβ/Smad2/3 pathway and disrupting the pro-fibrotic crosstalk between endothelial cells (LSEC)–hepatic stellate cells (HSCs). LSEC: liver sinusoidal endothelial cells, TGF-β: transforming growth factor beta, TβRI: TGF-β receptor I, TβR II: TGF-β receptor II, HSC: hepatic stellate cell.
