Table 3.
Incidence rates and HRs of death-censored graft failure according to blood pressure.
| Group | Number of participants | Graft failure | Follow-up Duration, Person-years | Incidence Rate, Per 1,000 person-years | Unadjusted, HR (95% CI) | Model 1, HR (95% CI)a | Model 2, HR (95% CI)b | Model 3, HR (95% CI)c |
|---|---|---|---|---|---|---|---|---|
| SBP, mmHg | ||||||||
| <100 | 394 | 32 | 2,432 | 13.2 | 0.795 (0.556–1.138) | 0.813 (0.568–1.164) | 0.763 (0.533–1.093) | 0.790 (0.552–1.131) |
| 100–119 | 4,401 | 456 | 27,587 | 16.5 | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| 120–129 | 3,705 | 454 | 22,495 | 20.2 | 1.222 (1.073–1.392) | 1.219 (1.070–1.388) | 1.173 (1.030–1.336) | 1.151 (1.010–1.311) |
| 130–139 | 3,592 | 561 | 21,442 | 26.2 | 1.586 (1.402–1.795) | 1.587 (1.401–1.797) | 1.448 (1.278–1.640) | 1.400 (1.235–1.586) |
| ≥140 | 2,157 | 431 | 11,847 | 36.4 | 2.212 (1.939–2.524) | 2.242 (1.962–2.562) | 1.894 (1.657–2.164) | 1.796 (1.571–2.055) |
| DBP, mmHg | ||||||||
| <70 | 2,391 | 261 | 14,370 | 18.2 | 0.931 (0.805–1.077) | 0.946 (0.817–1.094) | 0.935 (0.808–1.082) | 0.947 (0.818–1.096) |
| 70–79 | 4,948 | 590 | 30,234 | 19.5 | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| 80–89 | 5,120 | 764 | 30,893 | 24.7 | 1.269 (1.139–1.412) | 1.259 (1.130–1.402) | 1.207 (1.084–1.345) | 1.194 (1.072–1.330) |
| 90–99 | 1,348 | 220 | 7,921 | 27.8 | 1.424 (1.220–1.663) | 1.417 (1.214–1.655) | 1.274 (1.090–1.489) | 1.230 (1.052–1.437) |
| ≥100 | 442 | 99 | 2,385 | 41.5 | 2.137 (1.727–2.644) | 2.103 (1.699–2.602) | 1.859 (1.501–2.302) | 1.807 (1.459–2.238) |
| Pulse pressure, mmHg | ||||||||
| <40 | 2,392 | 227 | 14,713 | 15.4 | 0.792 (0.681–0.920) | 0.795 (0.684–0.924) | 0.779 (0.671–0.906) | 0.790 (0.680–0.918) |
| 40–49 | 5,709 | 691 | 35,461 | 19.5 | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| 50–59 | 4,220 | 661 | 24,916 | 26.5 | 1.364 (1.226–1.518) | 1.380 (1.240–1.537) | 1.235 (1.110–1.376) | 1.205 (1.082–1.342) |
| 60–69 | 1,433 | 235 | 8,140 | 28.9 | 1.487 (1.282–1.724) | 1.539 (1.325–1.787) | 1.289 (1.109–1.498) | 1.241 (1.067–1.442) |
| ≥70 | 495 | 120 | 2,573 | 46.6 | 2.411 (1.986–2.926) | 2.572 (2.112–3.133) | 1.976 (1.620–2.409) | 1.890 (1.550–2.306) |
BP, blood pressure; HTN, hypertension; HR, hazard ratio; CI, confidential interval; SBP, systolic blood pressure; DBP, diastolic blood pressure.
a
Model 1 was adjusted for age and sex.
b
Model 2 was adjusted for age, sex, low income, smoking, alcohol consumption, regular exercise, obesity, estimated glomerular filtration rate, and history of diabetes, cardiovascular disease and dyslipidemia.
c
Model 3 was adjusted for age, sex, low income, smoking, alcohol consumption, regular exercise, obesity, estimated glomerular filtration rate, and history of diabetes, cardiovascular disease and dyslipidemia, use of antihypertensive medications.