Table 2.

Review of association analysis for SNPs with M-AGA in FPHL studies [12,34,36,37,43,44,45,46,47].

Han Chinese *
Locus	SNP	Association with FPHL
1p36.22	rs12565727	No significant association
2q35	rs10193725	No significant association
	rs7349332
2q37.3	rs9752491	No significant association
	rs9711321
	rs12613833
3q25.1	rs4679955	No significant association
5q33.3	rs929626	No significant association
	rs1081073
7p21.1	rs2249817	No significant association
	rs12056282
	rs756853
	rs13230142
	rs17350355
12p12.1	rs7975017	No significant association
	rs9668810
18q12.3	rs10502861	No significant association
20p11	rs6137444	No significant association
	rs2180439
	rs1998076
	rs6113491
	rs201571
UK/Germany #
AR/EDA2R	rs4827379	Significant association in a subgroup with an early age of onset
	rs1397631
	rs2497938
	rs962458
	rs6152
	rs7885198
	rs5918801
1p36.22	rs2003046	No significant association
	rs12565727
	rs11576658
2q35	rs10193725	No significant association
	rs7349332
2q37.3	rs9711321	No significant association
	rs11683401
	rs9287638
3q25.1	rs7648585	No significant association
	rs4679955
5q33.3	rs929626	No significant association
	rs1081073
7p21.1	rs957958	No significant association
	rs2073963
	rs2073964
7q11.22	rs6947344	No significant association
	rs6945541
	rs4718865
12p12.1	rs9668810	No significant association
	rs7975017
17q21.31	rs12373124	No significant association
	rs17769552
	rs17650991
18q21.1	rs8083006	No significant association
	rs10502861
	rs12959797
20p11	rs6137444	No significant association
	rs2180439
	rs1998076
	rs201571
	rs6113491
CYP19A1	rs16964189	No significant association
	rs4646
	rs28757184
	rs2470158
ESR1	[44]	No significant association
PGR
SRD5A1
SRD5A2
ESR2	rs10137185	Significant association in the overall German sample
MC4R	[47]	No significant association
Australia $
CYP19A1	rs4646	CC genotype is significantly more frequent in some cases
ESR2	rs10137185	Nominal significance
	rs17101774
	rs2022748

* reference: [43], ^# references: [37,44,45,46,47], ^$ references: [34,36].