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. 2023 Jul 13;24(14):11427. doi: 10.3390/ijms241411427

Figure 6.

Figure 6

Enhanced angiogenesis in neuroendocrine organoids implanted into a mouse model following dynamic culture in RWV. Bag: static control culture in tissue culture bags. HARV: dynamic culture in HARV-type RWV Bioreactors. (Top) Whole organoid imaging using FITC-conjugated Griffonia simplicifolia lectin (green) to label the vasculature, overlaid with phase contrast (left). HARV condition shows denser vasculature. (Bottom) Fluorescent imaging of sections from Bag and HARV condition organoids showing better-formed vasculature throughout the organoid from the HARV condition. Reproduced with permission from Lelkes et al. [67].