Table 2.

Proposed functions of genes present around RO reductase NdmD in gDNA of Pseudomonas sp. [58].

Gene	Homologous Protein	% Identity	Organism/NCBI Accession Number	Proposed Function
orf1	S-formylglutathione hydrolase	75	Pseudomonas fluorescens WP_017340027.1	Involved in formaldehyde metabolism
NdmE	Glutathione S-transferase	86	Pseudomonas fluorescens WP_017340028.1	Structural protein/chaperone
NdmD	Oxidoreductase	81	Pseudomonas fluorescens WP_080995163.1	Reductase component of methylxanthine demethylases
NdmC	Aromatic-ring-hydroxylating dioxygenase subunit alpha	88	Pseudomonas fluorescens WP_017340030.1	Methyxanthine N7-demethylation
orf5	Hypothetical protein	92	Pseudomonas fluorescens WP_017340031.1	Unknown
orf6	Purine permease	88	Pseudomonas fluorescens WP_017340032.1	Transport of methylxanthines
NdmB	Aromatic-ring-hydroxylating dioxygenase subunit alpha	91	Pseudomonas fluorescens WP_017340033.1	Methyxanthine N3-demethylation
orf8	GntR family transcriptional regulator	91	Pseudomonas fluorescens WP_017340034.1	Repressor protein of methylxanthine operon
orf9	Membrane protein	83	Pseudomonas fluorescens WP_017340035.1	Unknown
NdmA	Aromatic-ring-hydroxylating dioxygenase subunit alpha	92	Pseudomonas fluorescens WP_031319057.1	Methyxanthine N1-demethylation
orf11	VOC family protein	83	Pseudomonas fluorescens WP_057008287.1	Metal dependent vicinal oxygen chelating enzyme
orf12	S-(hydroxymethyl) glutathione dehydrogenase	93	Pseudomonas fluorescens WP_046819641.1	Involved in formaldehyde metabolism

Note: Determination of homologous genes for each orf was conducted by performing a BLAST against the sequences available in the NCBI database.