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. 2023 Jul 19;24(14):11660. doi: 10.3390/ijms241411660

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The STRING network of GG+ genes (Table S1) corresponds to the 10th-16th evolutionary phylostrata. Genes (nodes) belonging to enriched functional modules of interest are displayed in the form of pie charts. The giant component of the network belongs mostly to MAGE-associated genes of spermatogenesis, it is connected to the subnetwork of the embryonic stem cell (ESC) and primordial germ cell (PGC) development. The link of MAGE-A11 to the androgen receptor (AR) is indicated by a red dashed line. The two genes sharing spermatogenic functions with brain development are yellow-marked. Hypergeometric test * p-value < 0.05; *** p-value < 0.001.