Table 1.
Significantly overexpressed genes in U87-ST8Sia3 cells relative to U87-MG cells. Significantly overexpressed genes (>3-fold change, p-value > 10−5) were annotated into functionally relevant categories. http://www.genecards.org and http://www.genome.jp/kegg/pathway.html were used for gene analysis.
| Category | Gene Symbol | Fold Change | p Value | Description |
|---|---|---|---|---|
| Signal transduction | TNFAIP6 | 6.23 | 7.88 × 10−14 | TNF-Alpha-Induced Protein 6 |
| Cell signalling | PLEKHA1 | 5.58 | 4.97 × 10−12 | Pleckstrin Homology Domain Containing A1 |
| Receptors | WDFY1 | 5.28 | 1.76 × 10−11 | WD Repeat and FYVE Domain Containing 1 |
| RNF139 | 5.05 | 1.19 × 10−10 | Ring Finger Protein 139 | |
| CSNK2A1 | 4.99 | 1.21 × 10−10 | Casein Kinase 2 Alpha 1 | |
| IL1B | 4.52 | 2.54 × 10−09 | Interleukin 1 Alpha | |
| TOLLIP | 4.10 | 3.63 × 10−08 | Toll Interacting Protein | |
| ADGRE1 | 3.86 | 2.75 × 10−07 | Adhesion G Protein-Coupled Receptor E1 | |
| TMEM14C | 3.55 | 1.10 × 10−06 | Transmembrane Protein 14C | |
| CIR1 | 3.53 | 1.23 × 10−06 | Corepressor Interacting With RBPJ, 1 | |
| RASA2 | 3.52 | 1.56 × 10−06 | RAS P21 Protein Activator 2 | |
| ROS1 | 3.50 | 1.38 × 10−06 | ROS Proto-Oncogene 1, Receptor Tyrosine Kinase | |
| IGFBP4 | 3.16 | 8.39 × 10−06 | Insulin-Like Growth Factor Binding Protein 4 | |
| PTBP3 | 3.09 | 1.34 × 10−05 | Polypyrimidine Tract Binding Protein 3 | |
| TNFAIP2 | 3.01 | 1.90 × 10−05 | TNF-Alpha-Induced Protein 2 | |
| Transcription | MAFF | 5.28 | 3.87 × 10−11 | MAF BZIP Transcription Factor F |
| Translation | MRTO4 | 4.57 | 2.86 × 10−09 | MRT4 Homolog, Ribosome Maturation Factor |
| MED21 | 3.74 | 4.11 × 10−07 | Mediator Complex Subunit 21 | |
| CHRAC1 | 3.70 | 4.96 × 10−07 | Chromatin Accessibility Complex 1 | |
| POLR2J | 3.57 | 1.67 × 10−06 | RNA Polymerase II Subunit J | |
| RPS17L | 3.48 | 1.42 × 10−06 | Ribosomal Protein S17 | |
| ZNF721 | 3.42 | 7.16 × 10−06 | Zinc Finger Protein 721 | |
| KANSL3 | 3.29 | 4.50 × 10−06 | KAT8 Regulatory NSL Complex Subunit 3 | |
| RPS7 | 3.22 | 6.15 × 10−06 | Ribosomal Protein S7 | |
| TSC22D1 | 3.10 | 1.14 × 10−05 | TSC22 Domain Family Member 1 | |
| OLIG2 | 3.05 | 3.27 × 10−05 | Oligodendrocyte Transcription Factor 2 | |
| TBX3 | 3.04 | 1.85 × 10−05 | T-BOX 3 | |
| Cell cycle | G0S2 | 5.56 | 2.52 × 10−12 | G0/G1 Switch 2 |
| Mitosis | PCNP | 4.42 | 4.42 × 10−09 | PEST Proteolytic Signal Containing Nuclear Protein |
| INSIG1 | 4.24 | 1.22 × 10−08 | Insulin-Induced Gene 1 | |
| CSNK1G1 | 3.35 | 3.31 × 10−06 | Casein Kinase 1 Gamma 1 | |
| Cell structure | MAP1LC3B | 7.46 | 8.77 × 10−18 | Microtubule-Associated Protein 1 Light Chain 3 Beta |
| Motility | IGFN1 | 5.66 | 6.48 × 10−12 | Immunoglobulin-Like Fibronectin Type III Domain Containing 1 |
| PDLIM2 | 5.54 | 1.45 × 10−11 | PDZ And LIM Domain 2 | |
| FIBCD1 | 5.36 | 2.05 × 10−11 | Fibrinogen C Domain Containing 1 | |
| LASP1 | 4.90 | 2.03 × 10−10 | LIM And SH3 Protein 1 | |
| CHI3L1 | 4.71 | 6.31 × 10−10 | Chitinase 3 Like 1 | |
| TWF1 | 3.62 | 6.12 × 10−07 | Twinfilin Actin Binding Protein 1 | |
| P4HA1 | 3.27 | 4.46 × 10−06 | Prolyl 4-Hydroxylase Subunit Alpha 1 | |
| TIMP3 | 3.26 | 1.11 × 10−05 | TIMP Metallopeptidase Inhibitor 3 | |
| KRT8 | 3.04 | 1.76 × 10−05 | Keratin 8 | |
| Mitochondria | ISCA2 | 3.61 | 8.91 × 10−07 | Iron-Sulfur Cluster Assembly 2 |
| Metabolism | PRDX1 | 6.69 | 3.03 × 10−15 | Peroxiredoxin 1 |
| CHST1 | 5.64 | 7.10 × 10−12 | Carbohydrate Sulfotransferase 1 | |
| PDXK | 5.36 | 1.00 × 10−11 | Pyridoxal Kinase | |
| HSD11B1 | 4.88 | 8.27 × 10−10 | Hydroxysteroid 11-Beta Dehydrogenase 1 | |
| HS3ST2 | 4.65 | 2.33 × 10−09 | Heparan Sulfate-Glucosamine 3-Sulfotransferase 2 | |
| COLGALT1 | 4.49 | 2.71 × 10−09 | Collagen Beta(1-O)Galactosyltransferase 1 | |
| PSMB7 | 4.04 | 1.03 × 10−07 | Proteasome Subunit Beta 7 | |
| NHLRC2 | 3.97 | 8.57 × 10−08 | NHL Repeat Containing 2 | |
| SLC44A1 | 3.92 | 1.01 × 10−07 | Solute Carrier Family 44 Member 1 | |
| DNAJB2 | 3.90 | 1.20 × 10−07 | DnaJ Heat Shock Protein Family (Hsp40) Member B2 | |
| AOC2 | 3.69 | 1.37 × 10−06 | Amine Oxidase, Copper Containing 2 | |
| ACSS2 | 3.49 | 1.34 × 10−06 | Acyl-CoA Synthetase Short Chain Family Member 2 | |
| AKR1C1 | 3.44 | 1.92 × 10−06 | Aldo-Keto Reductase Family 1 Member C1 | |
| Transport | SCOC | 7.50 | 1.83 × 10−17 | Short Coiled-Coil Protein |
| SLC25A42 | 4.23 | 2.81 × 10−08 | Solute Carrier Family 25 Member 42 | |
| SLC39A1 | 3.66 | 4.84 × 10−07 | Solute Carrier Family 39 Member 1 | |
| RAB5C | 3.65 | 1.11 × 10−06 | RAB5C, Member RAS Oncogene Family | |
| Others | CCDC117 | 4.24 | 1.74 × 10−08 | Coiled-Coil Domain Containing 117 |
| KIAA1755 | 3.72 | 8.03 × 10−07 | Unknown | |
| ICOSLG | 3.48 | 1.91 × 10−06 | Inducible T-Cell Costimulator Ligand | |
| BST2 | 3.46 | 3.74 × 10−06 | Bone Marrow Stromal Cell Antigen 2 |