Table 1.

MicroRNAs targeting Pim kinase in cardiovascular cell types.

MicroRNA	Target	Cell Type	Result	Ref
MiR-328	Pim-1	Pulmonary artery smooth muscle cells. Human umbilical vein endothelial cells	Overexpression of MiR-328 increases the level of Pim-1 and promotes proliferation. Inhibition of MiRNA-328 promotes angiogenesis in high glucose conditions by increasing Pim-1 expression.	[46,47]
MiR-214	Pim-1	Bone marrow-derived mesenchymal stem cells Vascular smooth muscle cells	PDGF increases the expression of this MiRNA, resulting in Pim-1 knockdown.	[32]
MiR-206	Pim-1	Mesenchymal stem cells in hypoxia Pulmonary artery smooth muscle cells.	Reduction in miR-206 causes increased proliferation and reduced apoptosis, which is protective in infarcted hearts.	[36,48]
Mir-1	Pim-1	Vascular smooth muscle cells	Myocardin increases the expression of Mir-1, which results in the inhibition of VSMC proliferation via the knockdown of Pim-1.	[49]
miR 410-5-p	Pim-1	Diabetic cardiomyopathy	MiR-410-5p inhibition decreases high glucose-induced myocardial apoptosis, preventing cardiomyopathy through the upregulation of Pim-1.	[50]
MiR-195	Pim-1	Sepsis—endothelial cells	Inhibition of miR-195 results in increased Pim-1, which is protective in a model of sepsis.	[51,52]