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. 2023 Jul 20;24(14):11695. doi: 10.3390/ijms241411695

Figure 2.

Figure 2

Pro-tumorigenic effects of NETs and developing therapeutic strategies. NETs have been demonstrated to play a role in tumor immunomodulation, camouflage, homeostasis/activation, and metastasis. Therapies under development can be grouped into those that prevent or “modulate” NETosis (the generation of NETs) or “dissolve” the chromatin “web” of the neutrophil extracellular trap, mitigating the ability for NETs to play a pro-tumorigenic role. HMGB-1, high mobility group box-1; KRAS oncogene mutation. Created with BioRender.com.