Table 2.
Baseline echocardiographic and ECG characteristics and differences between wtATTR-CM patients with and without ventricular tachycardia on Holter.
| ATTR-CM without Ventricular Tachycardia | ATTR-CM with Ventricular Tachycardia | p-Value | |
|---|---|---|---|
| n = 40 | n = 32 | ||
| Echocardiography (all: median, IQR) | |||
| Interventricular septal diameter (mm) | 19 (17–20) | 21 (19–22) | 0.006 |
| Left ventricular end-diastolic diameter (mm) | 43 (39–48) | 44 (39–49) | 0.972 |
| Left ventricular end-systolic diameter (mm) | 31 (27–36) | 33 (30–40) | 0.063 |
| Left ventricular posterior wall diameter (mm) | 15 (13–17) | 17 (15–19) | 0.026 |
| LV mass indexed for body surface area (g/m2) | 170 (132–199) | 198 (175–221) | 0.063 |
| Ejection fraction (Simpson, %) | 55 (48–57) | 47 (41–52) | 0.014 |
| TAPSE (mm) | 13.5 (12–18) | 14.0 (10–15) | 0.470 |
| Left atrial area (mm2) | 28 (24–32) | 31 (27–36) | 0.020 |
| Right atrial area (mm2) | 24 (21–29) | 24 (22–39) | 0.430 |
| E/e’ | 18.3 (13.8–21.5) | 17.7 (13.6–23.1) | 0.773 |
| GLS | −9.3 (−11.4–−7.9) | −8.4 (−11.5–−6.1) | 0.533 |
| Electrocardiogram | |||
| QRS-complex duration (ms; median, IQR) | 118 (103–140) | 116 (103–140) | 0.830 |
| QTc-interval duration (ms; median, IQR) | 481 (462–507) | 489 (468–509) | 0.325 |
| T wave inversion (n, %) | 9 (23) | 5 (15) | 0.553 |
| LBBB (n, %) | 2 (5) | 1 (3) | 1.000 |
| RBBB (n, %) | 5 (13) | 5 (16) | 0.746 |
| LAHB (n, %) | 12 (31) | 17 (53) | 0.089 |
| LPHB (n, %) | 6 (15) | 0 (0) | 0.029 |
| Low-voltage pattern (n, %) | 13 (33) | 7 (21) | 0.375 |