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Among solutions to CAR-T limitations which are likely to get to the clinic in the near future, combinations of authorised drugs with CAR-Ts are an important development to curb toxicities.
| Cytokine Causing CRS | Product Used in Combination |
|---|---|
| Granulocyte Monocyte Colony Stimulating Factor (GM-CSF) | Lenzilumab |
| Interleukin 1 (IL-1) | Anakinra |
| Proximal TCR Signalling Kinases, (Lck, etc.) | Dasatinib |
