LOXL2 protein structure. Arrows indicate the variable N-terminal domain and conserved C-terminal domain consists of several different functional domains, represented by boxes. Post-translational modifications of LOXL2 were obtained using UniProt. Modified residues are represented by blue triangles (phosphoserine at 601 and 722) and green triangle (2′,4′,5′-topaquinone at 689), while N-linked glycans at N288, N455, and N644 are marked with yellow stars. Si, signal peptide; SRCR, scavenger receptor cysteine-rich domain; Cu2+, copper binding domain; LTQ, lysine tyrosylquinone cofactor residues; CF, cofactor formation; CRL, cytokine receptor-like domain; PTM, post-translational modifications. The figure drawing is not-to-scale (for detailed LOXL2 structure, see Meier et al. [44]).