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. 2023 Jul 21;24(14):11745. doi: 10.3390/ijms241411745

Table 1.

LOXL2 inhibitors for HCC and liver fibrosis.

Type Agent Target References
monoclonal
antibody
AB0023 LOXL2 [46,121,122]
AB0024 LOXL2 [123,124,125]
small-molecule
inhibitor
BAPN LOX/LOXL1-4 [100,133,134]
LOXL2-IN-1 LOXL2 [122]
PXS-5338 LOXL2 [156]
PXS-5382 LOXL2 [156]
PXS-5878 LOXL2 [156]
PXS-5153A LOXL2/LOXL3 [157]
(2-chloropyridin-4-yl) methenamine LOXL2 [158]

BAPN, beta-aminopropionitrile; PXS, (2S)-propane-1,2-diyl dihexadecanoate.