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Design of stapled TP10 analogs.
| Peptide | Sequence |
|
| TP10 (F-1) | CF-XAGYLLGKINLKALAALAKKIL | |
| F-2 | CF-XAS5*YLLS5*KINLKALAALAKKIL | |
| F-3 | CF-XAGYLLGKINLKALAAS5*AKKS5*L | |
| F-4 | CF-XAGYS5*LGKS5*NLKALAALAKKIL |
The C-terminus of each peptide had an amide (NH2) group. CF = 5(6)-carboxyfluorescein, X = β-alanine. The cyclization between i and i + 4 of the two (S)-4-pentenylalanine (S5) residues is indicated by an asterisk.
