Table 1.
Analysis of the Log2 fold change of the expression of genes in the one-carbon metabolism and the nucleotide synthesis pathways in mouse (Mm) and human (Hs) ATCs compared to normal thyroids. Genes overexpressed in all three datasets are indicated in bold.
| Gene name | Mm (GSE30427) | Hs1 (GSE65144) | Hs2 (GSE76039) |
|---|---|---|---|
| One-carbon metabolism | |||
| DHFR | 1.076 | 0.748 | 1.465 |
| SHMT1 | 0.767 | −1.356 | −1.470 |
| SHMT2 | 1.684 | 1.795 | 1.714 |
| MTHFD1 | 0.79 | 1.029 | −1.362 |
| MTHFD1L | 1.359 | 1.465 | 2.144 |
| MTHFD2 | 2.625 | 2.195 | 2.751 |
| MTHFD2L | 0.459 | 0.322 | −1.561 |
| ALDH1L1 | −0.718 | 0.310 | nc |
| ALDH1L2 | 3.86 | 1.722 | 0.465 |
| Nucleotide synthesis | |||
| TYMS | 1.587 | 2.888 | 3.966 |
| GART | 0.363 | 0.918 | 0.986 |
| PAICS | −0.509 | 1.007 | 1.541 |
| ADSL | 0.963 | 0.465 | nc |
| ATIC | 1.01 | 0.595 | 0.978 |