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. 2023 Jul 24;24(14):11860. doi: 10.3390/ijms241411860

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Antibody-mediated inhibition of caveolin-1 blocks S protein pseudovirion infection of ARPE-19 cells. (A) Caveolin-1 is expressed in ARPE-19 cells; immunoblot visualized with anti-caveolin-1 antibody (*; green). (B) Fold difference in uptake of original spike-pseudotyped lentiviruses at MOI 10 in the presence of Anti-caveolin-1 antibody (PA1-064) at 1:500 dilution (1 µg/mL) and 1:250 dilution (2 µg/mL) at 24 h compared to untreated controls infected with original spike protein pseudotyped particles alone. * p < 0.01, **** p < 0.0001.