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. 2023 Jul 24;24(14):11860. doi: 10.3390/ijms241411860

Figure 12.

Figure 12

Classic inhibitors of caveolae-dependent endocytosis do not affect S protein pseudovirion infection of ARPE-19 cells. (A) Left panel: Fold difference in uptake of original spike-pseudotyped lentiviruses in the presence of 100 nM–10 μM nystatin at 24 h (□) and 48 h (■) compared to untreated controls infected with original spike protein pseudotyped particles only. Right panel: % Cell viability in MTT assay at various concentrations of nystatin. (B) Left panel: Fold difference in uptake of original spike-pseudotyped lentiviruses at MOI 10 in the presence of 100 nM to 10 μM indomethacin at 24 h (□) and 48 h (■) compared to untreated controls infected with original spike protein pseudotyped particles alone. Right panel: % Cell viability in MTT assay at various concentrations of indomethacin.