Table 1.

PECO formulation.

In vivo studies
Population	All mammalian species
Exposure	Exposure to xenon (all doses, timings, and routes of administration)
Comparator	Control animals not exposed to xenon Control animals exposed to an antagonist for a proposed site of xenon action Wild type animals (when compared to knockout animals)
Outcome	Quantitative data on the expression of proteins or mRNA Behavioral outcomes or injury quantification outcomes in which a target for xenon is identified
In vitro studies
Population	Cell models of neurons Cultured neurons Brain and spinal cord tissue slices Single bouton preparations of neurons
Exposure	Exposure to xenon (all doses, timings, and routes of administration)
Comparator	Cells or tissues not exposed to xenon or following xenon washout Cells or tissue models exposed to an antagonist for a proposed site of xenon action Wild type receptor models (when compared to transgenic receptor models)
Outcome	Electrophysiological measurements of ionic current Quantitative data on the activity of membrane transport proteins Quantitative data on the expression of proteins or mRNA Injury quantification outcomes in which a target for xenon is identified